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KMID : 0366219840190020309
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Korean Journal of Hematology
1984 Volume.19 No. 2 p.309 ~ p.321
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Hematologic Findings of Myelodysplastic Syndrome
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박찬정/Chan Jeoung Park
조한익/김상인/이재훈/김병국/김노경/Han Ik Cho/Song In Kim/Jae Hoon Lee/Byoung Kook Kim/No Keoung Kim.
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Abstract
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Myelodysplastic syndrome is characterized by variable cytopenia in peripheral blood
and hyper or normocellular bone marrow due to bone marrow stem cell dysfunction. It
was recently classified into 5 subtypes by the French-American-British(FAB)
Cooperative Group.
Hematologic findings of 57 cases of myelodysplastic syndrome were studied at the
department of clinical pathology, Seoul National University Hospital from 1981 January
to 1984 June. Applying FAB criteria, we found: refractory anemia (RA) in 20 cases
(36%): refractory anemia with excess blasts (RAEB) in 17 cases (30%) : RAEB in
transformation (RAEB in tf) in 15 cases (26%) : chronic myelomonocytic leukemia
(CMML) in 3cases (5%) and RA with ring sideroblasts (RA c ring SB) in 2 cases(4%)
. Male: female ratio was 1.7:1. Age distribution was relatively even except slight
predilection between thirty and sixty years. In peripheral blood pancytopenia was found
in 36 cases (63%), leukocytosis in 11 cases (19%) and relative monocytosis in 11 cases
(19%). Various dyspoietic changes of erythrocytes, leukocytes and platelets were
observed. In bone marrow hypercellular marrow was found in 35 cases (61%)
normocellular in 9 cases (16%), hypocellular in 6 cases (11%) and variable cellularity in
7 cases (12%). Myelofibrosis was observed in 14 cases (25%), Erythroid hyperplasia and
myeloid hyperplasia was found in the half of cases and megakaryocytic hypoplasia in 35
cases (61%). Various dyspoietic changes of 3 cell lines were also observed.
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